Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,896 – 2,910 of 5,528 results

2,896

TARGETMOL CHEMICALS INC MK2-IN-1 HYDROCHLORIDE 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MK2-IN-1 hydrochloride (MK 25) is a highly selective non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2 IC50 0.11 uM) [1]. purity: 99%

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2,897

Medchemexpress LLC 4',7-Dimethoxyisoflavone | 1157-39-7 | 10 MM 1 ML

4',7-Dimethoxyisoflavone, also known as Dimethoxydaidzein, is a natural compound isolated from the leaves of Albizzia lebbeck. It exhibits antifungal activity against various plant pathogenic fungi and is intended for research use only.

Isolated from Albizzia lebbeck
Exhibits antifungal activity
For research use only
High purity (98.20%)
White to off-white solid appearance
Soluble in DMSO

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2,898

Medchemexpress LLC (Ser8)-GLP-1 (7-36) amide, human | 215777-46-1 | 99.1% | 3313.63 | 50 MG

(Ser8)-GLP-1 (7-36) amide, human is a glucagon-like peptide 1 amide derived from glucagonogen. It is a cleavage product of the GLP-1 (1-36) amide peptide. This compound acts as an entero-insulinotropic hormone, which means it stimulates the release of insulin from pancreatic β-cells in a glucose-dependent manner. Additionally, it influences gastrointestinal motility and secretion. The product is intended for research purposes only and is not for sale to patients.

Derived from glucagonogen, a cleavage product of GLP-1 (1-36) amide peptide.
Functions as an entero-insulinotropic hormone.
Induces glucose-dependent insulin release from pancreatic β-cells.
Affects gastrointestinal motility and secretion.

Pricing & Availability

2,899

eMolecules 17455-13-9 | 1,4,7,10,13,16-Hexaoxacyclooctadecane | Apollo Scientific US - Building Blocks | MFCD00005113 | 264.318 | C12H24O6 | 98.000 | C1COCCOCCOCCOCCOCCO1 | 25g | 397996927

1,4,7,10,13,16-Hexaoxacyclooctadecane | Apollo Scientific US - Building Blocks | 17455-13-9 | MFCD00005113 | 264.318 | C12H24O6 | 98.000 | C1COCCOCCOCCOCCOCCO1 | 25g | 397996927

Pricing & Availability

2,900

eMolecules 1612792-88-7 | potassium;[trans-2-ethoxycarbonylcyclopropyl]-trifluoro-boranuide | Pharmablock440.080 | C12H18B2F6K2O4 | 0.000 | [K+].[K+].CCOC(=O)[C@H]1C[C@@H]1[B-](F)(F)F.CCOC(=O)[C@@H]1C[C@H]1[B-](F)(F)F | 250mg | 812213421

potassium;[trans-2-ethoxycarbonylcyclopropyl]-trifluoro-boranuide | Pharmablock | 1612792-88-7440.080 | C12H18B2F6K2O4 | 0.000 | [K+].[K+].CCOC(=O)[C@H]1C[C@@H]1[B-](F)(F)F.CCOC(=O)[C@@H]1C[C@H]1[B-](F)(F)F | 250mg | 812213421

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2,901

Medchemexpress LLC N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester | 1401089-31-3 | 99.3% | 430.47 | C21H22N2O6S | 50 MG

PACMA 31 is an irreversible small-molecule inhibitor of protein disulfide isomerase (PDI) used for biochemical and cell-based research. It covalently modifies PDI active-site cysteines, has a reported IC50 of about 10 μM, shows tumor-targeting activity in preclinical models, and contains an alkyne group compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.

Irreversible PDI inhibitor that covalently modifies active-site cysteines.
Reported IC50 of approximately 10 μM for PDI activity inhibition.
Demonstrated tumor-targeting activity in preclinical studies.
Contains an alkyne functional group for CuAAC click chemistry applications.
Solid form and high reported purity suitable for research use.

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2,902

Medchemexpress LLC SKA-31 | 40172-65-4 | 99.7% | 200.27 | 50 MG

SKA-31 is a potent potassium channel activator that potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure. It is suitable for research use only.

Potent potassium channel activator with specific EC50 values for KCa3.1, KCa2.2, KCa2.1, and KCa2.3.
Potentiates endothelium-derived hyperpolarizing factor response.
Lowers blood pressure.
Activates KCa2/3 channels more potently and selectively than other activators.
Not acutely toxic and has good pharmacokinetic properties.
Stimulates KCa3.1 and KCa2.3 in vascular endothelial cells, increasing acetylcholine-induced endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilation.

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2,903

Medchemexpress LLC Fmf-06-098-1 | 2769753-07-1 | 98.8% | 1073.76 | 25 MG

FMF-06-098-1 is a multi-target kinase PROTAC degrader that targets degradation kinases such as AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1. The compound is composed of a target protein ligand, a VHL ligand, and a linker.

Store powder at -20°C for 3 years, or 4°C for 2 years.
Store in solvent at -80°C for 6 months, or -20°C for 1 month.

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2,904

Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 1mg, CAS: 130370-60-4.

Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development

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2,905

Medchemexpress LLC Super-TDU (1-31) TFA | 99.3% | 3355.50 | 5 MG

Super-TDU (1-31) TFA is a peptide fragment derived from Super-TDU, functioning as an inhibitor of the YAP-TEAD complex. This compound demonstrates potent anti-tumor activity and effectively suppresses tumor growth in gastric cancer mouse models. It is intended for research use only and largely compromises increased cell viability induced by ACTN1 in liver cancer cell lines.

Inhibitor of YAP-TEAD complex.
Shows potent anti-tumor activity.
Suppresses tumor growth in gastric cancer mouse models.
Can compromise increased cell viability induced by ACTN1 in Huh-7 or LM3 cells proliferation.
Available in various quantities for research needs.

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2,906

Apexbio Technology LLC R 59-022 93076-89-2 10mg

R 59-022 (CAS 93076-89-2) is a small molecule inhibitor of diacylglycerol kinase (DGK) demonstrating an IC50 of 2 8 M for DGK activity By inhibiting the conversion of 1-oleoyl-2-acetylglycerol to phosphatidic acid R 59-022 modulates diacylglycerol signaling pathways The compound also exhibits antagonistic effects at serotonin (5-HT) receptors and can induce activation of protein kinase C (PKC) In cellular studies R 59-022 enhances thrombin-induced diacylglycerol accumulation in platelets and suppresses phosphatidic acid formation in neutrophils It serves as a valuable tool for investigating DGK-mediated processes and signal transduction mechanisms

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2,907

Medchemexpress LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.

Potent antimicrobial agent with LTA biosynthesis inhibition.
Inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL.
Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
Inhibits pro-inflammatory cytokines.
Directly binds to PgsA.
Downregulates the expression level of PgsA, an essential protein for phospholipid synthesis.

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2,908

Apexbio Technology LLC STF 31 724741-75-7 50mg

STF 31 (CAS 724741-75-7) is a small-molecule inhibitor targeting glucose transporter 1 (GLUT1) with an IC50 of 1 M By antagonizing GLUT1 STF 31 disrupts glucose uptake selectively impairing survival in VHL-deficient renal cell carcinoma (RCC) models that depend on enhanced glycolysis In vitro STF 31 exhibits selective cytotoxicity toward VHL-deficient RCC4 cells while exerting minimal effects on RCC4/VHL controls In vivo administration of STF 31 analogs retards tumor growth in VHL-deficient RCC xenografts without notable toxicity in mice STF 31 is utilized in research to investigate GLUT1-mediated metabolic dependencies and therapeutic vulnerabilities in cancer and neuroinflammatory models

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2,909

Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 | C11H12N2O7 | 100 MG

Mal-amido-(CH2COOH)2 is a maleimidoethyl-containing intermediate used as a hydrophilic linker building block in antibody-drug conjugate (ADC) synthesis. It is supplied as a white to off-white solid with high purity and is intended for research use only. Typical applications include conjugation chemistry and linker assembly where maleimide reactivity and carboxylic acid functionality are required.

Maleimide functional group for thiol conjugation.
Hydrophilic spacer with two carboxylic acid termini.
High purity suitable for research applications.
Available in multiple package sizes including 100 mg.
Characterized by 1H NMR and LC-MS data.
Comes with datasheet, COA, and SDS documentation.

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2,910

eMolecules 50440-85-2 | 2-AMINO-5-CHLORO-4(3H)-QUINAZOLINONE | AstaTech | MFCD22194766 | 195.610 | C8H6ClN3O | 97.000 | Nc1nc2cccc(Cl)c2c(=O)[nH]1 | 1g | 323611217

2-AMINO-5-CHLORO-4(3H)-QUINAZOLINONE | AstaTech | 50440-85-2 | MFCD22194766 | 195.610 | C8H6ClN3O | 97.000 | Nc1nc2cccc(Cl)c2c(=O)[nH]1 | 1g | 323611217

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Quinolines and derivatives

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Medchemexpress LLC 4',7-Dimethoxyisoflavone | 1157-39-7 | 10 MM 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (Ser8)-GLP-1 (7-36) amide, human | 215777-46-1 | 99.1% | 3313.63 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester | 1401089-31-3 | 99.3% | 430.47 | C21H22N2O6S | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SKA-31 | 40172-65-4 | 99.7% | 200.27 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fmf-06-098-1 | 2769753-07-1 | 98.8% | 1073.76 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Super-TDU (1-31) TFA | 99.3% | 3355.50 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 | C11H12N2O7 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More